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How to combine cannabis strains effectively

Do you like to smoke a combination of strains during a session sometimes? Evidence suggests that toking on a mixture of bud can increase your high and improve the flavors you’re tasting from the herb. Depending on the cannabinoid profile, a strain may help to reduce your high if you’ve smoked some very strong stuff. Sometimes adding a strain can intensify an experience.

In this article, we’ll explain why combining multiple strains can be a clever strategy and give you some ideas about which strains go well in tandem.

Can combining cannabis strains enhance your high?

If you consider yourself a cannabis connoisseur, then the chances are you’ve already combined strains before when you’ve experimented. But perhaps you haven’t stumbled across an exhilarating mix that increases – or otherwise changes – your high. There are two main explanations as to why mixing strains can have a positive effect on your cannabis trip.


Recreational users will surely be familiar with psychoactive tetrahydrocannabinol (THC), the most important and abundant cannabinoid found in both cannabis indica and cannabis sativa. Cannabinoids are rare and pretty much only found in cannabis – more than 110 unique cannabinoids have, however, been found in the cannabis plant. From the compounds that have been studied, we can confirm that cannabinoids tend to offer potential medical benefits with few to no side effects.

Cannabidiol (CBD) was always considered the secondary compound in cannabis. But the fact that it can produce therapeutic effects without making the user high has seen interest in CBD skyrocket. The compound reduces anxiety, can have a positive effect on mood, and when it is combined with THC, both cannabinoids are more effective.

The synergy created by a CBD-THC combination enhances the pain-relieving properties of cannabis. Moreover, CBD products manage to cancel out some of the psychoactive effects of THC thanks to its anti-psychotic properties. Cannabis experts refer to the synergy between cannabis compounds as the “entourage effect,” and it’s why full-spectrum and whole-plant products are usually preferable to isolates. Such products also contain other cooperative cannabinoids like THCV and CBDV, and aroma-providing terpenes.

Researchers have drilled down on tetrahydrocannabivarin (THCV) lately and are confident that this cannabinoid is responsible for the energy boost that sativa strains are famed for. A study of THC and THCV found that the cerebral high is enhanced when both compounds are present. When used together with CBD, THCV may help with weight loss and management, having exhibited appetite suppressant properties. This could help patients with diabetes and those struggling with obesity.


The flavor and aroma of a cannabis strain comes solely from the terpene compounds. These aroma molecules also have therapeutic effects and are influential in the “entourage effect” process. Both terpenes and cannabinoids are found in the trichomes (resin glands) on cannabis – these are situated on the leaves and buds of the plant.

The slight variation in cannabinoid and terpene profiles means that the synergistic effect is a little different from strain to strain – hence why similar strains can produce polar opposite effects. Whether a plant is deemed an indica or sativa often depends on which terpenes are present – 0.5 percent myrcene is usually enough for a strain to be considered an indica.

Myrcene is an interesting terpene that has a significant effect in pretty much every strain it appears. This compound, which is also found in mangoes, is thought to increase the amount of THC absorption into the brain, leading to a more intense high. Myrcene also has sedative properties.

THC already has bronchodilatory effects, but terpenes such as pinene can help to increase these. Therefore, strains with high levels of pinene may help to increase your oxygen flow, which may come in handy when you’re exercising.

Which strains should you pair together?

Ready to start experimenting with the entourage effect and find a pair of strains that can enhance your high in some way? Here are some combinations that we enjoy. When mixing strains, it’s best to check out the cannabinoid and terpene profiles beforehand – then you can make an informed choice rather than trust to luck.

1) Sour Diesel and Granddaddy Purple

These strains have little in common but pair them up and watch them fly. The diesel-like aroma of the Sour Diesel complements the fruity flavors of the Granddaddy Purple surprisingly well. As far as the effects go, this is an indica-sativa mix, so expect to feel the best of both – a sweet body high that leaves you sealed to the sofa, as well as cerebral activity that stimulates your creativity.

On its own, Sour Diesel is an energizing strain, like any good sativa. When you mix it with Granddaddy Purple, anticipate feeling chilled out, relaxed and with enough brainpower and will to concentrate on any jobs or creative projects.

The exact effects you’ll receive from pairing these strains depends on the ratio. But a roughly equal mix should give you the sensations of a world-class hybrid.

2) Charlotte’s Web and Durban Poison

This combo looks to make the most of the synergy between CBD and THCV. There are few known strains that have more THCV than Durban Poison, and the same goes in terms of CBD for Charlotte’s Web. The high-CBD strain, which is used to make cannabis oil for epilepsy treatments, regularly consists of 20 percent CBD.

The psychoactive rush of Durban Poison will be toned down considerably by Charlotte’s Web, so this mix won’t suit a recreational user. But for those who want mellow medicating with limited sedation, giving your CBD treatment a shot of THCV will help keep you energized and alert.

3) Cheese and Blue Dream

Cheese and Blue Dream is a combination that will knock your socks off – that goes for both flavors and effects. An American hybrid favorite for many years, Blue Dream boasts a pungent blueberry aroma. Cheese is an indica-dominant hybrid – while this bud also has a strong aroma, it’s somewhat muskier than Blue Dream’s. Both great strains as they are but put them together and you have something really special.

Blue Dream’s sedative properties can be amplified with a dash of cheese, increasing your couchlock as you enjoy an uplifting yet calm high. This relaxing mixture is best enjoyed just before bedtime and can help you enjoy a full and healing night’s sleep.

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