CBD Pain Cream by Genesis

(4.86 based on 118 customer reviews)

$29.99$49.99Spend $50 and get free shipping!

Comes in a 2oz bottle.

Under 0.3%
Lab Certified
This is The Best Product for tight, overused muscles. You can actually feel the relief before you stop rubbing it is. I give it A TEN!!! - Vickie 

Product Description

Ingredients: Essential Oil, Organic Alcohol Extract of Salix Alba (Organic White Willow) Bark, Xanthan Gum, Tetrasodium EDTA, Naturally Occurring CBD in Hemp oil 200mg

Genesis CBD Pain Cream Review

The market for topical CBD-infused creams has exploded in recent times. Research has shown that cannabinoid receptors from the endocannabinoid system are situated in the skin. This means that cannabinoids such as cannabidiol (CBD) can have therapeutic effects when applied externally.


As the name of this product suggests, CBD-rich creams can help with pains. They are also great for providing relief from inflammation and relaxing muscles, particularly post-exercise. We’ll touch more on these benefits later in the article.

Ingredients used

This CBD topical cream has been made with a full-spectrum CBD extract. The lab reports for both the 250 and 500mg products confirm the high CBD content of these products, and that the amount of psychoactive THC is below the legal 0.3% limit.


Full-spectrum CBD is made with all of the hemp extract, and therefore contain trace quantities of other cannabinoids and terpenes. There may be limited research on many of these compounds in their individual state, but studies show CBD is more effective when part of a full extract, compared to when taken isolated.


This CBD Genesis Pain Cream is also made with beneficial essential oils, xantham gum and an organic alcohol extract of Salix Alba bark, which is a natural exfoliant for the skin.

Reasons for using a CBD cream

In this section, we’ll cover some general reasons for using the CBD Genesis Pain Cream. This list is not exhaustive, but should give you some guidelines for use.

Chronic pain relief

Lots of CBD products are thought to help with chronic pain – these include edibles, tinctures and e-liquids. However, for targeted relief from pain, topical products stand out. As the CBD stays in one place, the analgesic effects are all concentrated on the area where the CBD was applied. If you are managing lower back pain, for instance, the benefits will all be felt in this region.


How does CBD relieve pain? Scientists are not 100 percent sure on the mechanisms, just that it can have a positive effect. It is perhaps thanks to CBD inhibiting breakdown of the endocannabinoid anandamide (AEA). AEA is a CB1 receptor agonist, a cannabinoid receptor in the ECS that regulates pain sensitivity. Furthermore, CBD is a vanilloid receptor agonist – this receptor is not a part of the ECS, but it does affect how the body feels pain.

Inflammation relief

CBD is an excellent anti-inflammatory, so it’s possible to use CBD for arthritis pain. The two types of arthritis are rheumatoid and osteoarthritis.


Rheumatoid is an autoimmune disease – CBD may help here by restoring regulation to the ECS, and with it the immune system. Osteoarthritis is a result of wear and tear, and CBD can alleviate joint pain, and may work to repair damaged joint cartilage.


The reductive effect of CBD on inflammation means creams could also be used to treat swelling and bruising.

Muscle relaxation

The microscopic muscle tears which can occur after an intense workout are not, contrary to opinion, bad, but they can cause discomfort and soreness. Any of us who exercise are familiar with this pain, but it is manageable with a CBD cream for pain. Lather up, and you’ll help to alleviate the notorious aches which set in after working out.

For skin conditions

While you should exercise caution with using this pain cream on sensitive skin, it has the potential for helping with less volatile skin conditions. Applying CBD to the skin minimizes the risk of fungal, microbial or bacterial infections, as the cannabinoid helps stop the spread of all three.


Moreover, as a natural anti-inflammatory, CBD may reduce symptoms of psoriasis, acne and eczema. Cannabinoid receptors (in this case, CB2) are found in the skin, which is why CBD topicals can be used to tackle skin-based inflammation.

Pain Cream Range

Creams and topicals are the only CBD-infused products that have a localized effect. When you apply it to the skin, the cannabinoids are kept in the skin, and are not transported around the body in the blood. Therefore, these do not have a direct effect on your mood. However, you may find that your mood improves anyway if the cream helps to relieve your pain. We have two CBD creams for pain, sold in 2oz pots with 250 or 500mg of CBD.


The 250mg cream is good if your symptoms are not too severe. The CBD has a soothing effect on the skin, which is great for relaxing the muscles. It will also help with pain, although to get the benefits make sure you apply at regular intervals.


The 500mg cream is twice as strong, and is intended for people in search of more potent relief. This CBD pain salve will be more effective at relieving intense, chronic pain, as there is more CBD present to interact with the various receptors – both inside and outside of the ECS – in the skin.

A word of advice

As stated on the packaging of this CBD Genesis product, it should be kept away from the eyes. Ensure that you are only using this product topically, and show due care if applying to sensitive skin. It’s recommended to only use a small quantity of the cream each time, but to apply every four to six hours if necessary.

Final thoughts

Our very own CBD Genesis Pain Cream has all the ingredients required to provide meaningful, cannabinoid-based relief for the skin, helping to improve skin quality and reduce inflammation and pain.


Please note that this CBD Genesis Pain Cream product is not intended to treat, cure or prevent any disease. These statements have not been evaluated by the Food and Drug Administration (FDA).


The contents of this article are purely informational, and serve as an introduction as to how people are using CBD topical alternatives in place of prescription medications. However, this article is not medical advice, and if you are in need of medical help, consult with a physician.


118 reviews for CBD Pain Cream by Genesis

  1. Richard Walton

    Works great on body as well as vaping it. Highly recommend.

  2. Alisha

    Great Product!

  3. Brittany

    Been using it for 4 years and I can’t go without it. Instant pain relief and soothes all my migraines perfectly. Thank you for creating such an awesome product. Mahalo🤙

  4. Caressa

    Smells good and works as expected.

  5. Vickie

    This is The Best Product for tight, overused muscles. You can actually feel the relief before you stop rubbing it is. I give it A TEN!!!

  6. Nicole

    This saved my butt during a covid illness..

  7. Theresa

    The Genesis cream is also helpful for arthritis in the hands and painful knees. Rubbing just a little on the area helps to relieve flair ups of pain.

  8. PEGGY

    I purchased the 500mg cream. This is the only brand that helps with my pain (shoulders, knees, hip). I will purchase this item again.

  9. Amanda Barrett

    Worked wonders for muscle pain.
    Will order again.

  10. JEREMY

    This stuff is truly amazing. My wife and I both use Genesis CBD pain cream and it works wonders for us. I have lower back pain and my wife has chronic nerve pain. After applying this cream, the pain is gone within minutes. Highly recommend!

  11. Tanisha

    Great product and arrived in a timely manner!

  12. Richard

    It helps with body aches and if you get migraines put some on your temples you will feel better within 5 minutes, any migraine sufferer knows what a blessing that can be

  13. Richard

    If you suffer from arthritis or carpal tunnel this should be your new go to a little bit goes a long way too! I would rate this product 10 out of 5 stars.

  14. Carmen

    This cream works like a charm! I have OA in my knees & this pain cream is wonderful. Thank you.

  15. Madeline

    LOVE this cream, it really works!

  16. Debra

    Great for headache, calming minty smell

  17. Debra

    Love this cream, very good for headaches. Very calming smell.

  18. Debra

    Love this cream, very good for headaches. Very calming smell.

  19. Madeline

    This cream is amazing! My husband and i bith use almost daily , I’m so glad I found and gave it a try!

  20. Vicki

    My husband and I love this cream. We rub it on sore hips, knees, and backs at night. We sleep great and feel great in the morning.

  21. Claudia

    I bought this for my mom. She has knee problems and is always in pain. She started using this and swears by it! It works really well. I’m already recommending this to people I know that need it.

  22. Richard Gillis

    I highly recommend this pain cream. I have carpal tunnel syndrome and this helps better than any over the counter medications or cream and the smell is not too strong just right.

  23. Catherine

    Pain s gone every time I use this cream!! Love, love, it!!!

  24. Barbara

    Use for muscle atrophy on TBI patient.

  25. Ivy Reynolds

    From a surgery perspective: I purchased the 500mg. I had a double mastectomy with a scarless latissimus dorsi flap reconstruction. The area above my breasts “burn” from the inside and my skin is terribly sensitive to the touch. I applied a thin layer to my chest. It works. The relief lasted about 30 minutes. My husband also applied a liberal amount to the areas around (not on) the incisions on my back. Very effective with the stinging & pulling pains. Lasted over an hour. The smell is just ok and in my opinion needs improvement.

  26. John

    Excellent cream. It helped my arthritic pain like nothing else I have found on the market. Highly recommend this product.

  27. Tallula

    I really enjoyed both products. I\’ve used this cream before and it really works, I was not able to find a substitute in Nashville so I had to go with this cream, it\’s awesome.

  28. Madeline

    My husband and i have tried both the 250 and 500 mg creams…they are wonderful !! We use daily and im amazed that it works on my nerve pain as well. So grateful to find this. This company is awesome, always great service, awesome products!

  29. Carol

    I will never be without this cream… great stuff!

  30. Patricia

    Love the 500mg it is my go to for any ailment from head to toe and works in just seconds ….thank you

  31. Mackenizie

    Works great for pain, bought it for my mom for her knee after she had surgery and she loves it

  32. Shannon

    This is a life saver for pain… i have some kind of hip issue and as soon as i started using it the pain stopped… I cannot wait to try the 500 mg.

  33. João

    My wife uses it on her knees and she feels great.
    Now I need to order 2 more CBD cream 500mg.

  34. JEREMY

    I ordered the 250mg Genesis Pain Cream for my wife who suffers from nerve damage. She has noticed almost immediate relief and has also decreased her medication intake as a result. We also use 1500mg Genesis CBD as well for joint/back pain as well as treatment for anxiety + mild depression. I will continue to only purchase Genesis CBD products because I have tried other brands before, and they do not compare to Genesis products. Thanks so much for making life changing products!

  35. Patricia

    I prefer the 500MG…its all very effective ….friends and family find it works wonders for many things …glad to have a great product and great customer service

  36. Patricia

    Oh what a relief it is ..works fast and even works to keep mosquito bites from itching…my go to for all my sore joints …thank you

  37. Mary

    I bought the pain cream for recurrent severe pain in the left side of my back/neck area. Unfortunately, the weather is so hot in the Phoenix area,
    (It came via the regular mail), it melted in the mailbox! When I opened the jar, half the contents spilled out. I don’t know if the active ingredient comes to the top or it’s just psychological, but it doesn’t relieve the pain like I was told it would. The quality of your product is high, so I would be willing to try it again.
    Thank you

  38. Patricia

    Love this stuff for achy joints and muscles …guess what it works on mosquito bites and an itchy rash that happens to pop up from out doors or wherever…fast cast relief

  39. Patricia

    I use the 500 mg …works fabulous…everyday for the pain and healing ..thanks for being true to the natural

  40. Kimberly

    We love this cream. It helps my mom with her legs and hips and allows her to sleep through the night.

  41. Danny

    Great product for pain relief.

  42. Sandra

    Thank you it was sent quickly and works very well

  43. Troy

    I purchased this for my wife who suffers from knee pain .She used it and claims that it does relieve her knee pain .

  44. Cat

    Love this cream…sent from heaven no doubt!!!

  45. Catherine

    Love this cream…takes my pain away better then pills!!!

  46. Anthony

    Bought pain cream for my dad, 88 years old and suffering from chronic muscle pain. 2 weeks after using cream, he is back to cutting grass, working on things around house and feeling no pain. Excellent product, great price and super fast delivery.

  47. Kimberly A

    This product has been a life saver. My dad and myself have chronic pain. Using this product helps to make the pain bearable. I refer this product to my friends with pain issues.

  48. tammy

    still a bit pricey for the amount of cream in the jar

  49. Catherine

    This pain cream was sent from heaven. It is the best pain reliever and I will keep on buying it…

  50. Catherine

    Love this cream..it is making my life better and pain free

  51. Ken Woolfe

    Seems about as good as ibuprofen or Salonpas pads for mild joint pain/inflammation (bursitis, sciatica). I use very little so it should last a long time.

  52. Kenneth

    I haven\’t used it a lot but it appears to work about as well as ibuprofen or Salonpas pads for shoulder (bursitis) and hip (mild sciatica). I\’m using very little so it will last a long time.

  53. Stuart

    The CBD Pain Creme from CBD GENESIS has a pleasant odor and isn\’t greasy. It absorbs into the skin quickly and pain is relieved for 4 or more hours. I\’ve used it on my legs and back with good results.

  54. Dawn

    The best. Please make this available asap.

  55. Raymond

    I bought this for my daughter in the 500 strength for her arthritis pain. She has had so much relief.

  56. Cristina

    This is something that I will always keep in my arsenal to help with pain.

  57. Dean

    Cream works well and has helped me with pain and sleep.

  58. Cory

    Works great and smells great. I’m quite satisfied.

  59. Dana

    Great pain cream!

  60. Kimberly

    Great Product!!! I highly recommend this cream. Helps with leg pain.

  61. Humberto

    works amazing fast on my elderly parents.

  62. Kathy

    I have arthritis in many joints of one foot and at times it can be very painful walking. Ordered some 500mg CBD pain cream. It arrived within a few days. It was amazing how quickly I felt relief after I rubbed it in. Slight odor but not objectionable. I cannot use products with camphor, as they make my skin feel like it is on fire. This is great! Thank you!

  63. paul

    works great

  64. Kimberly

    This stuff is great! It truly eases pain and helps with relaxation.

  65. Lynette

    I have neuropathy and this cream really helps with the burning in my feet. I use it several times a day. However, it does not work as well the first time you apply it as it does the fifth time. It takes time and a few applications to calm the nerves. The is by far the best cream I have found!

  66. Laurel

    Great pain cream I have RA and it helps alot

  67. Tabitha

    Didn’t help my nerve pain. Might need something way stronger

  68. Ronald

    Works great!!!

  69. Corry

    I was looking for 250 mg cream and this was economical and mail order. It’s working great, relieving a lot of my arthritis pain.

  70. Daniel

    Timely shipping. Works great on pain! Hoping it removes a growth on the ear, will keep trying, since nothing conventional has worked so far. Thank you!

  71. patricia

    This is the best pain cream for sciatica nerve pain, works instantly. thank you 🎉

  72. Joan

    I had the 250 which I loved but then I tried the 500mg one which is great I use both depending on the pain… haven’t tried the pixie stick yet! I’ve told relatives about how great the service is and they’ve bought lotions and vap juice! Awesome site and always get the things you order in no more than 3 days.. keep up the good work❣️

  73. Michael

    Ive been training for a marathon in august cuz fat Burnt Chrysler ran the L.A. marathon without training. I rub this on my feet at night and I sleep like Ive drank 17 titos and sodas. This stuff works great

  74. Debra

    Great for pain relief. Fast helpful service.

  75. keith

    Feels good

  76. Jeremy

    My wife uses this cream daily. She deals with chronic joint pain and this gives her relief. We will continue to use this & other Genesis CBD products.

  77. Chris


  78. Adam

    Fantastic product will order again

  79. User

    This cream is magical. I suffer from knee problems, back problems, arthritis everywhere, the list goes on. I apply this cream where needed when needed, and not only does it bring relief, it buys me more time of not needing the relief…..sometimes a week will go buy before i need to apply it again. Better than any holistic cream/salve, and prescription cream I’ve ever had.

  80. Rebecca

    Great for pain management. Size of container is perfect for taking with me. Able to apply cream while at work without any worries.

  81. Elizabeth Chavez

    Awesome stuff ! Works really great on my lower back pain and scatica. Hoping they restock soon.

  82. Joan K

    Excellent results for PAIN ! KEEP it coming. Wouldn’t mind more DISCOUNT CODES ! HINT

  83. Kimberly

    This helps ease my pain so I can actually sleep through the night. I will keep buying this product!!!

  84. adam

    Outstanding, very good value.

  85. Kimberly

    I love this product. It works great for pain relief. I even have my 73 year-old mom using this for her pain and she loves it.

  86. alan

    seemed to work for pain

  87. Anna

    this cream is even better then I thought it could be. I just wish it was cheaper..

  88. Vernita

    Had bilateral total knee replacements a year ago and been in pain since. Found out have 2 staph infections in one knee and a problem with tendon in the other. I will be going through 3 morw surgeries to correct these problems. This product has been a Godsend to me!! If it wasn’t for it, I could not walk the length of Walmart without being in pain. I will NEVER go without having this cream on hand, because I know how much relief it has given me. Even if my knees ever get fixed correctly, I will keep this on hand for any other pains I may get.

  89. Sherri

    Love this

  90. Patricia

    We love the cream!!

  91. Daniel

    Great pain cream i use it on my ankle where i uad surgery

  92. joshr152

    This product works great for long lasting pain relief in my joints. Just a small amount goes a long way. I’ll make sure I never run out since I can move now without being in pain.

  93. Michael

    Great product. Rub on and pain starts to go away. Would like to see a higher concentration of CBD.

  94. Joy

    This cream is amazing. I have repurchased 16 more jars. I have customers coming back asking when I will get it back in stock. My experence has been to apply lightly on area of pain, once it has absorbed, reapply to same area. I have seem it work on sciatic nerve in customers back and leg, I have saw it work on lower back pain , shoulder pain and also heard raving reviews for skin issues from my customers. Will always keep in stock.

  95. Catherine Patarak

    I bought this cream 2 times now….it works great…I have low back pain..foot pain ..knee pain. It last me 2 months. Its the best cream ever!!

  96. Patricia

    We loved this

  97. Carol

    CBD pain cream I have found… well worth every penny. A little goes a long way!!

  98. Ernie

    This product works wonders. Having chronic pain on my foot for over 14 yrs this product has given me relieve unimaginable

  99. Alesa

    This stuff really helps my back! I even put it on my temples when I get a migraine

  100. Kate

    This CBD cream works wonders. I have a painful trigger finger problem and could barely move my right ring finger. This cream has improved my finger about 80%.

  101. Alesa

    Great stuff really works!

  102. Sheila

    I have RA and it effects my hands a lot, I used this cream to relieve the throbbing pain. It has helped.

  103. Ernie

    All I can say I finally found some relieve without prescription pain medication. I suffer from severe nerve damage on my foot that\’s cause chronic pain for the last 11 yrs. This CBD pain cream works great and has relieved my pain level from 95-100%. I can sleep now without the pain keeping me awake. Thank you CBD Vape Juice

  104. Kate

    Works really well. I did a huge amount of yard work this summer and injured my right hand. This cream takes the pain away and lasts several hours. I just ordered more.

  105. laurie

    love this pain crème. use it during massages for pain reduction. Very positive feedback from clients. Highly recommended

  106. Joe

    Got some for my wife to use on her hands/carpal tunnel after a long day and she absolutely loves it and feels much better the next morning.
    Lightweight and generic looking jar makes traveling with it a breeze.
    So now I keep ordering it before she runs out!

  107. Jamianne

    Unfortunately, this cream didn’t work for me. I didn’t notice a difference in my sore muscles. It’s lightweight which is nice and the shipping came very quickly.

  108. Callen

    Really good stuff

  109. gibarra09.psn

    Fast shipment great product. Been using it for some chronic pain in hends, neck and on my chest.

  110. Richard

    Easy to order, fast shipment, product as expected. Product does what is advertised and expected within minutes.

  111. Callen

    Great stuff! Have tried out on a family member with arthritis who has swollen hand joints and it has took down the swelling straight away and eased the pain. Also tried it on other pain and very effective stuff!

  112. James

    Have every kind of pain possible this stuff really works. Rub on sore areas, within minutes I’m cbdreamin!!!!

  113. James

    Stuff worked awesome!!! Rubbed it in within minutes my pain was gone and muscles and joints were loose and alive for the first time in years. Thanks genesis.

  114. Janet

    Awesome product! Great for joint pain. Also, helps relieve headaches when rubbed into temples.

  115. Dianna Sweeney

    I really didn’t believe this would work on the pain in my hands. Nothing else really has. Not even the pain medication that I use. But I have to admit that it is an amazing product. And as an added bonus it leaves my hands so soft and it has a pleasant fragrance as well. Anyone with arthritis and other chronic pain issues will find this incredibly helpful.

  116. Jerry Calderon

    Good product , we make our own salve and this will give my customers more options , great product

  117. Tony

    I had major shoulder surgery. This cream gave me so much relief it’s unreal. Ordering more now. I don’t wanna run out. Awesome product!

  118. Carol

    I will NEVER let this product run out in my house. As soon as it arrived I rubbed some on my sore neck and within two minutes I could feel the relief. I also have recently lost 145 pounds and cannot sit for long periods of time without my tailbone hurting (less rump padding) … last night I rubbed a very small amount on my tailbone and it helped sooo much! We have been doing a LOT of gardening and home improvement projects as its finally spring here in Michigan and I have used it on my achy hands and feet and my husbands shoulders and neck also… totally convinced this product can easily replace our regular OTC pain killer products. You really don’t need a ton either. Just a dab will do ya!

Add a review

Your email address will not be published. Required fields are marked *

Pain Cream Lab Results

You may also like…