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Understanding the structural composition of CBD

Most people know about the THC cannabinoid in marijuana – especially recreational users, because it’s the compound that gets them high (but it does have medical qualities too). Historically, the lesser known, but still vitally important cannabinoid has been cannabidiol (CBD).

But what exactly does CBD do, and does it get you high? And if not, why not?

First off, no, CBD doesn’t get you high, but it is full of awesome therapeutic qualities, from treating rare seizures to acting as an anti-anxiety agent, which can be taken in the form of CBD vape oil, edibles, tinctures, creams, gels and concentrates.

Some CBD products contain just CBD, others are labelled full-spectrum (includes other cannabinoids and terpenes except THC), and in legalized states, or states with expansive medical marijuana systems, you can buy whole-plant medication which contains THC as well.

And secondly, no, you won’t get high off CBD – but that’s a good thing, given its main uses are medical. The non-psychoactive nature of CBD has allowed the compound to become the first choice medication for children with uncommon ailments such as Dravet’s syndrome, a severe and life-threatening form of epilepsy. To understand why CBD behaves as it does, let’s delve into the structural composition of cannabidiol.

Many factors affect how well cannabinoids will bind to receptors in the body. These include how the cannabinoid acts around water and the electrostatics of it. Interestingly, CBD and THC have a fairly similar structural makeup, but the slight differences result in CBD’s bond to receptors being three to five times weaker than THC’s.

In CBD’s molecular structure, there is a break in the ring, in a direct contrast to THC. This break gives CBD the opportunity to make an extra hydrogen bond and double bond to THC, which leads to the charge variation between the two cannabinoids.

Furthermore, CBD doesn’t just have a weaker bond to the CB-1 receptor than THC – it causes a completely opposite effect to the psychoactive compound. To understand why, we must look even deeper into marijuana biochemistry.

The shape and charge distribution differences in CBD compared to THC significantly affect the strength of the bond and its due reaction, but the CB-1 receptor also behaves differently when interacting with the two.

The CB-1 structure is a fairly new concept even to scientists, with the endocannabinoid system only recently being discovered. However, we do know that CB-1 receptors are considered G-protein coupled receptors (GPCRs). These receptors, which in reality are signaling proteins, are extraordinarily complex. Here’s what you need to know about their structure.

The CB-1 structure is made up of sensitive helices that permeate through the receptor’s cellular membrane. They are powerful and react in various ways when CBD or THC binds to them.

It’s the sensitivity of the helices that explain the vast differences between CBD and THC, despite the cannabinoids having a similar structure. On their own, the effects would not be that pronounced, however CB-1 receptors are designed to multiply the signals they are given, causing minor variations become major.

And that’s just one reaction that takes place between receptors and the cannabinoids that bind to them. When you think that there are many of these that occur inside the cell when the two interact, it’s clear to see why marijuana biochemistry is so complicated!
In the grander scheme of things, the tiny chemical reactions that take place may seem irrelevant, yet they are crucial to enhancing our understanding of the cannabis plant and how other cannabinoids and compounds interact. Unlocking this knowledge will allow cultivators and manufacturers to develop products even more suited to consumers than we have already.

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Understanding the intricate reactions between CBD, THC and receptors

The reactions between receptors in the endocannabinoid system and cannabinoids can vastly differ on just the tiniest of structural changes, hence why CBD and THC have such contrasting effects despite their similar compositions. The behavior of the protein (receptor) is as influential in the overall reaction as the structure of the cannabinoid.

Let’s find out more about the supposition that CBD and THC have opposite reactions in the body.

Scientists have researched the behavior of both CBD and THC, and also investigated how CBD alters the effects of THC – functional magnetic resonance imaging (fMRI) has proven a game-changer in helping us learn more about these reactions.

An fMRI is essentially an MRI, but in video format. MRIs enable doctors to see inside us by surveying our body’s waters using magnets. The movie from an fMRI, allows researchers to study changes in real-time, specifically determining which parts of the brain are activated or stifled from the introduction of various compounds, like CBD and THC.

Doctors also have psychological tests that they can carry out on participants, to study cognitive changes from smoking cannabis. These may include alterations to sensory and emotional processing, response inhibition and verbal memory. The tests have been carefully fine-tuned over several decades to ensure that any changes are solely down to the marijuana (or any stimulus being investigated) and no other factors.

Dr Sagnik Bhattacharyya and his research team devised a test involving CBD, THC and a placebo (flour). The placebo was used to provide a baseline for the scientists, so that they could tell exactly which reactions were down to the cannabinoids. They used capsules containing 10mg and 600mg of THC and CBD respectively for the experiment.

Standard double-blind testing and semi-random distribution was used for the experiment, to guarantee that participants had no way of working out whether THC, CBD or flour was being administered.

Interestingly, all of the psychological testing conducted on the participants produced the same result, and one that CBD advocates were hoping for: that the cannabinoid does not affect cognitive functions in any way – the responses were exactly the same as the placebo flour. Therefore, scientists could confidently conclude that CBD isn’t psychoactive and cannot get the user high. Expectedly, the THC testing did elicit changes in cognitive behavior – but we were already well aware of THC’s psychoactive properties.

The researchers also used the testing opportunity to study how the brain responded to the cannabinoids and placebo.

They found that six parts of the brain were affected by marijuana, and that THC and CBD were activating those same six parts. What the scientists hadn’t bargained for, however, was that their effects would be totally opposite.
Take the occipital lobe, which controls muscle memory: it was inhibited by THC yet activated by CBD.

The researchers did leave a disclaimer that the changes in behavior between the cannabinoids may not necessarily be just down to the molecular structure of the two, and that further experimentation would be required to determine whether there are other contributing factors. But they did conclude – with certainty – that CBD cannot get you high and that cannabidiol affects the brain (in the six activated areas) completely differently to THC.

Now, it’s up to Bhattacharyya and co to establish precisely why these reactions occur.

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The FDA wants to hear your views on CBD

The Food and Drug Administration (FDA) has clearly been showing interest in CBD lately, admitting that the compound had “beneficial” properties.

Now, the federal agency wants to hear your user experiences with CBD, in particular its therapeutic advantage and its potential for abuse, as a part of drive to become more aware of several controlled substances.

The World Health Organization (WHO) has also been studying CBD, and could soon schedule the drug for international use. If this happens, the US would be under pressure to do the same as part of an international treaty on drug policy from 1961. This explains why the FDA wants to get informed about CBD.

The legal status of marijuana, hemp products and CBD is extremely confusing, especially with all the minor law differences from state to state. At federal level, the uncertainty arises on the legality of CBD, as it’s found in both regular marijuana and industrial hemp plants.

With governments in many parts of the world recognizing the medical qualities of CBD, for the federal government to keep the cannabinoid as Schedule I, a classification for substances with “no medical use” that mainly consists of harder drugs, is clearly unacceptable. But in late 2016, a new code relevant to CBD only reaffirmed the DEA’s prohibitive federal position.

The “Establishment of a New Drug Code for Marihuana Extract” code was brought in quietly, so that the DEA could track researchers with access to CBD for testing more closely. So while scientists are trying to determine the precise medical benefits of CBD, law enforcement are getting involved in totally counter-productive fashion.

Therefore, it seems quite odd that the FDA wants the views of the public, given that they’re keeping a close eye on researchers, whose scientific data will be far more valuable to them than the public’s anecdotal experiences.

But there’s never a bad time to tell the federal government just how important medical marijuana is – and this time, they’re even prepared to listen! If tens of thousands of law-abiding cannabis users could share their stories of how CBD has improved their lives, federal prohibition may finally have a chance of being erased.

Momentum is on marijuana’s side, with more than one-third of states having laws that explicitly vouch for CBD’s therapeutic traits. Recently, the US National Institute on Drug Abuse (NIDA) went on the record, calling CBD a “safe drug with no addictive effects.”

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Patients choosing CBD over pharmaceutical meds, according to new survey

According to a recent survey, CBD is proving to be a more relieving option for patients than traditional prescription medication, and that women especially have been beneficiaries from the shift.
Brightfield Group and HelloMD carried out a huge research program, featuring responses from 2,400 of HelloMD’s estimates (around 150,000, as of 2017). The findings showed that men favored using THC-rich products, but that women accounted for 55 percent of all CBD users.

HelloMD’s chief medical officer Dr Perry Solomon noted that anxiety, depression, insomnia and joint pain were popular reasons for using CBD, for both men and women.

Solomon said that CBD products are experiencing an “exponential rise” in interest, as more patients realize that the cannabis compound could help them too. She also added that the majority of CBD users were enjoying its benefits and that while scientists still have much to discover about the cannabinoid, the future seems a positive one.

The survey found that 42 percent of participants who used CBD had cast aside prescription medication that they deemed had nasty side effects, was addictive or as simply ineffective. Encouragingly, four-in-five described the CBD products they had used to be “very or extremely effective” with a mere 3 percent reporting little to no effect. CBD e-liquid, CBD oils and tinctures, CBD edibles and CBD lotions are just some of the available products in states with sufficient marijuana laws.

Brightfield Group director of research, Bethany Gomez, called the study “exciting,” commenting that it showed CBD’s potential is “huge” and “barely-tapped.”

Millions of Americans already use CBD and millions more could soon be finding relief from this ground-breaking, herbal alternative. Gomez briefly mentioned America’s growing opioid crisis, and if those taking opiate-based medication could be enticed to a safe, natural medication like CBD, lives might just be saved too.

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Investigating the reactions between THC and CBD

Historically, THC (scientifically known as delta-9-tetreahydrocannabinol) has received all the plaudits for causing marijuana’s effects. And, while THC is a key compound in cannabis (and essential to recreational users seeking a high), CBD (cannabidiol) is another cannabinoid which deserves recognition for its powerful, all-encompassing, therapeutic traits.

It’s also said that CBD actually reduces the high of THC, by binding to the same receptors. Let’s investigate whether this is true, and if so, why this reaction happens.

Our bodies is made up of several systems (e.g. nervous system, respiratory system), but scientists were late to discover what would become known as the endocannabinoid system (ECS), which has the ability to influence mood, pain perception, appetite and other variables. Cannabinoids like THC, CBD and CBG bind to receptors in the ECS, in fairly complex fashion.

The CB-1 and CB-2 receptors are the most dominant receptors in the ECS, with CB-1 attracting the most attention for its interactions with THC, as the changes caused by it are what lead to the psychoactive high that we connect to smoking marijuana.

We know that CBD and THC activate the same six parts of the brain, and that despite this their effects are not even slightly alike. Furthermore, comprehensive psychological tests have proven that CBD on its own has no impact on the body’s cognitive functions. This is even more fascinating considering the similar molecular composition of THC and CBD.

However, new research also suggests that CBD is able to suppress the high of THC. From a medical point of view, this is encouraging news, since THC-isolate medication caused cases of anxiety and paranoia in some participants. A few people are unable to smoke THC-dominant marijuana for the same reasons. It’s maybe thanks to its anxiolytic qualities that CBD is able to level out a THC high.

But with euphoric sensations not experienced from a THC-isolate high, surely CBD has a part to play in the “high” from smoking marijuana. And it’s euphoria which is most sought after by recreational smokers.

One could argue that the high comes completely from the THC, and that the CBD’s inhibiting effect helps bring it down to a more pleasant and manageable level. Or maybe CBD is synergistically modulating the THC.

We won’t really know until more research is conducted in the “entourage effect” area – this is the term to describe the multiplier effect from whole-plant medicine (meds containing CBD and THC). However, we can confidently say that if you want to get stoned, you’ll need the whole package – CBD, THC, CBG and every other cannabinoid, terpene and compound found in the plant or concentrate.

CBD is the ideal way to medicate with marijuana if your job requires you to pass drug tests, if it’s not practical for you to get stoned or if you have a principle against mind-altering substances. Thanks to the industry’s development, there are now suitable options for all potential users.

Now we just need the federal government to reassess its firm opposition to marijuana, so everybody can benefit from its therapeutic abilities.

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Indiana’s state government remains confused on the legal status of CBD

Confusion continues to reign in Indiana, with state officials now even admitting that they’re unsure of the legality of CBD products, just weeks after a raid on a grocery store which saw hemp-based CBD oil seized.

Indiana State Excise Police raided a Fresh Thyme Farmers Market in the Indianapolis region, using the statute that it’s illegal to sell “fake drugs” to consumers as reasoning for seizing the hemp-derived products.

However, it appears that Indiana law enforcement has mixed up hemp CBD and marijuana-derived CBD, which was recently made legal as medicine for selected ailments and will soon be available to patients providing they have a doctor’s recommendation.

The Indiana Alcohol and Tobacco Commission were initially supportive of the raid, but Chairman David Cook has conceded that it’s a “complicate issue”, as reported by local NBC affiliate station WTHR. Cook notes the various opinions on the legality of possessing and selling hemp-based CBD oil, adding that law enforcement will refrain from seizing it until the confusion has been cleared up.

WTHR also challenged Indiana’s state government, reaching out to the state attorney for their view.

Jeremy Brilliant, spokesman for Indiana’s state attorney general said that the state government was also confused about what is and isn’t legal, before adding that it’s the job of the attorney general’s office to bring clarity to the matter.

He also said that the attorney general was cooperating with state agencies in an attempt to find answers, but that there was no timeframe for when the office may reach a conclusion on hemp-based CBD’s legal position.

But is it really the job for Indiana’s Alcohol and Tobacco Commission and the Excise Police to restrict or grant access to cannabinoid products, given that CBD is neither alcohol nor tobacco?

The medical marijuana law passed in Indiana in April 2017, as limited as it is, may shed some light. The finer details indicate that it is the Indiana State Department of Health that has the authority to make decisions on CBD oil products containing less than 0.3 percent.

However, the Excise Police’s raid of Fresh Thyme Farmers Market happened in mid-June. The aforementioned legislation didn’t come into place until a fortnight later on July 1.

That raid was the only one of its kind, with other vendors in Indiana continuing to sell these CBD products without trouble. But the Fresh Thyme Farmers Market lost out on several thousand dollars’ worth of hemp CBD products in the raid, and has not been compensated.

Georgetown Market, which also operates in the Indianapolis area, were bullish in an interview with WTHR, making clear that they will keep offering CBD oils and creams to their customers.

Owner Rick Monteith spoke of the need for the community to “make a stand” and push forward on the belief that CBD should be legal and accessible in every US state.

Momentum may be swinging Monteith’s way, with the US Food & Drug Administration (FDA) recently declaring for the first time that CBD has “beneficial” qualities. For a federal government agency to speak positively about CBD is unheard of, but maybe this will be a foundation for long overdue federal legislation.

The FDA recognizes that CBD has been “beneficial in experimental models” for neurological disorders such as epilepsy (e.g. Dravet’s syndrome), in a report which featured in the Federal Register. Clinical testing of CBD products on humans is now underway in the United States and positive findings there could pave the way for future FDA approval. However, at present, the FDA doesn’t deem CBD to have medical purposes despite using the term “beneficial” to describe it.

Furthermore, the statement reasserted that CBD continues to be classified under Schedule I of the Controlled Substances Act. Substances on this list are deemed to have no medical uses. Removing CBD from Schedule I will be the first step, as this will help increase accessibility for users and researchers.

But there’s another twist, concerning the Single Convention on Narcotic Drugs, an international treaty from 1961 on global drug policy which the United States is meant to be legally bound to. The Expert Committee on Drug Dependence (ECDD), a branch of the World Health Organization (WHO) is currently researching CBD. America would, in all likelihood, have to reschedule CBD if the ECDD determines that CBD has medical uses.

There’s more good news than bad for CBD. The Indiana incident was very unusual, with the feds largely taking a backwards step on CBD and concentrating on other areas. They won’t give up their anti-marijuana agenda altogether – at least not yet.

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Indiana’s CBD saga concludes with an apology

Nobody could have guessed when Indiana’s House and Senate passed a bill in April to allow approved patients access to CBD medication that it would create such confusion and chaos.

But what was initially a welcome and progressive move has caused much embarrassment, especially for Indiana law enforcement that seems not to have understood its finer details.

A mix up between CBD medication, intended for use by patients with treatment-resistant conditions such as Dravet’s syndrome (a rare form of epilepsy), and hemp-derived CBD, a health supplement, led to a raid at a grocery store in Indiana, and the seizure of perfectly legal products by an over-eager police force.

It’s clear that Indiana enforcement messed up with this raid, but what created the confusion in the first place, and do CBD users in Indiana need to be worried about a future crackdown?

Law enforcement’s confusion over new ‘CBD-only’ law

Hemp-based CBD products are legal providing they contain less than 0.3 percent THC (the psychoactive cannabis compound), but it was these products that were being confiscated by police. These raids, a direct result of not knowing the law, have disadvantaged those hoping to use CBD as medicine.

According to local news, police conducted several raids until late June 2017, when the legality of them was brought into question. And now it’s clear that the seized products didn’t contain any THC at all, Indiana State Excise Police look to be backtracking from their position – if only they could have worked this out before seizing them.

Lawmakers and officials in the Hoosier state are still disputing the finer details of CBD’s legal status, but an email acquired by the Indianapolis sheds the most light on why these raids even occurred. According to the email, one notable police commander believed that, because of the new law, CBD products could only be used as epilepsy treatment, and if they were found being sold or used for any other purposes they could be confiscated.

The result of this misunderstanding was the raid of almost 60 stores in Indiana and the seizure of more than 3,000 legal CBD products over a five-week stretch. Frustratingly, CBD has had assured legal status in Indiana since 2014 when the state introduced a hemp law, taking hemp products off the controlled substances list.

What’s next for CBD in Indiana?

The good news for Indiana’s CBD users is that a September police press release seemed to admit the mistake. The release says that Indiana State Excise Police’s raids of stores selling hemp-based CBD products will stop and that, from now on, only products in violation of state law will be seized.
However, the police also made it clear that they will keep “monitoring” events, and “remain prepared to take enforcement action” should the need arise.

The “unless the products clearly violate Indiana law” part of the police press release could do with some clarification, though. Hopefully Curtis Hill, Indiana’s Attorney General, will offer some when he delivers his expected formal opinion on the situation.

None of this is ideal for medical CBD users though, who should now be receiving the much-needed CBD oil they have the right to. Not being able to access products, or living in constant fear of prosecution because law enforcement doesn’t know the law, is a horrible situation for patients and families – who have already been through enough – to be put in.
It’s paramount that those with life-threatening conditions are able to get the CBD medication they need. Officials and legislators have a responsibility to fully understand new legislation, and particularly ‘CBD-only’ legislation which is notorious for causing confusion, to prevent future chaos.

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Indiana raid confusion leads to seizure of legal hemp-based CBD oil

In concerning news for CBD users in Indiana, a new NBC affiliate story suggests that the state’s law enforcement does not understand the CBD laws of its own state.

WTHR reported on a raid at a Fresh Thyme Farmers Market conducted by Indiana State Excise Police, seizing large quantities of a health supplement styled and sold as CBD oil.

However, it turns out that the hemp-based product seized by the authorities was actually perfectly legal according to federal and Indiana state law. New legislation does permit access to marijuana-derived CBD oil for epilepsy patients, but this is a completely different product that was not being sold at the market.

Indiana remains one of the most anti-marijuana states in America, but did at least pass a bill in early 2017 that has allowed certain patients to acquire the CBD oil medication needed for their treatment-resistant ailments. To get this CBD oil, a doctor’s recommendation is needed, as opposed to hemp-based CBD oil which can be purchased over a counter. Indiana legislation doesn’t allow the same for marijuana-based CBD oil.

However, it continues to be a waiting game for Indiana patients, who will not receive their CBD oil until regulations have been set up to go with the new law. The plan is for approved patients to be able to get CBD medicine at Indiana pharmacies.

Hemp-derived CBD oil is often sold as a health or dietary supplement at grocery and health stores around the nation. The CBD in these products is extracted from industrial hemp seeds, whereas in regular CBD oil, the whole plant – especially the CBD-rich buds – are used. This means less plant matter is needed to extract the same amount of oil.

Industrial hemp is, in botanical terms, a strain of cannabis sativa, it just has many differences. For example, the CBD concentration levels in hemp are typically much lower than in regular marijuana, while industrial hemp contains only tiny amounts of THC (so tiny that the federal government doesn’t even consider it marijuana, providing the THC level is below 0.3 percent).

The marijuana used for standard CBD oil can have CBD concentrations in excess of 15 percent, a stark difference to industrial hemp where levels can be as low as 20 parts per million. At these levels, these hemp-derived oils don’t really have any medical benefits.

However, the Indiana police force doesn’t see it that way, justifying their raid at the Fresh Thyme Farmers Market with a statute which prohibits the sale of “fake drugs”.

A spokesperson for the Indiana Alcohol and Tobacco Committeee told WTHR that it’s illegal to possess or sell CBD oil in the state of Indana, and that this applies to licensed liquor and tobacco establishments.

Those selling the hemp-derived CBD oil are now set to face preliminary charges for possessing cannabis as well as a “counterfeit controlled substance.”

The case is yet to be reviewed or commented on by the Marion County prosecutor’s office, and this raid looks to be an anomaly. Let’s hope law-abiding vendors in Indiana are left alone.

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Exploring Pure CBD Exchange’s world-class isolates

CBD consumers have better choice than ever before, with new companies always emerging onto the market. Pure CBD Exchange is one such brilliant brand, with a lovely range of truly world-class products. Ethically sound, they make the bold, impressive claim that all of their products are pesticide-free, and back it up with comprehensive laboratory testing.

Pure CBD Exchange’s Isoterp Shatter may be the pick of them, with this concentrate not only being immensely powerful, but wonderfully tasty too. The cherry-flavored vapor produced when dabbing this isolate is divine, with lower temperatures accentuating the fruity notes even more so.

The best CBD isolate products always boast more than 95 percent purity, and Pure CBD Exchange’s isolates are firmly in this category. But simply being potent and pure doesn’t necessarily make a great isolate – it’s the flavor and experience that really matters, and Isoterp Shatter performs fantastically in both departments.

They also make great tinctures, based on either hemp seed oil or MCT oil. These are unlike many CBD tinctures on the market, in that they are made with full-spectrum oil, not CBD-isolate oil. Therefore, Pure CBD Exchange tinctures are loaded with other non-psychoactive marijuana compounds to help recreate the “entourage effect,” a multiplier effect theory that suggests CBD is more powerful when interacting with other compounds and not isolated.

For their supreme quality, Pure CBD Exchange products are very well-priced. If you’re keen to start dabbing isolates like crystal or shatter, the like of Isoterp Shatter are perfect to get your feet wet.

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Enjoy a relaxed, steady high with these 8 amazing CBD edibles

For new cannabis users, the high levels of psychoactive THC can make for an uncomfortable high. But CBD products, and in particular CBD edibles, are proving an excellent way for novices to balance out the sensations and enjoy a more relaxing experience.

CBD (cannabidiol) is non-psychoactive and interacts with the endocannabinoid system in such a way that it reduces the effects of the THC. Some find that THC-isolate products, and even regular marijuana can induce anxiety, but with its anxiolytic qualities, CBD products are a great way to eliminate this side effect.

CBD can also be very therapeutic on its own, acting as a relaxant, an analgesic for pain relief, an anti-inflammatory and even an anti-depressant. Many take CBD during the daytime to enhance their mood, whereas others prefer evening use to bring them in to a sedated state and improve their sleep.

When buying marijuana products, whether bud or extract, check out the THC to CBD ratio beforehand. As far as edibles go, users tend to opt for high CBD ratios, but there are cannabis products available for every type of user.

Let’s take a look at eight CBD edibles the marijuana world loves at the moment.

1) CBD Living Gummies by CBD Living (CBD: 10mg)

Another perfect low-dose choice, these gummies are full of flavor and also include vitamin D and vitamin B-12 – great for calming your high or delivering steady pain relief over a few hours.

2) Lemon CBD Candies by Paradise Candy Company (CBD: 15mg or 50mg)

These hard lemon candies are sold in low and high dose potencies, providing various levels of relaxation. Handily, Paradise Candy individually wraps the candies, so there’s no need to worry about your edibles going ‘off’. The more potent Apple Sativa and Watermelon Indica candies are also made by Paradise.

3) Espresso Dark Chocolate by Kiva Confections (CBD: 60mg, THC: 60mg)

This chocolate bar edible tastes exactly like dark chocolate, but with some espresso notes – it also has a delicious, silky texture. The bar is split up into four equally-sized segments with 15mg of CBD and THC in each. These are perfect for low-dosing, but if you’re after more of a kick, the Ginger Chocolate bar from Kiva Confections is available at double the potency.

4) Sugar-Free CBD Zinger by VCC Brands (CBD: 100mg, THC: 15mg)

Lemon and ginger really do make this CBD Zinger zing, and with a CBD to THC ratio in excess of 6:1, expect a tranquil, soothing and happy, if not euphoric trip. The CBD Zinger cookie is vegan and diabetic-friendly.

5) CBD Mango Cannabis Quencher by VCC Brands (CBD: 40mg, THC: 40mg)

Containing CBD, THC and the myrcene substance from mangoes, which some reckon helps absorb THC, the CBD Mango Cannabis Quencher is an excellent tropical beverage.

6) Ginger Snaps by Sow Eden Organics (CBD: 10mg)

Sow Eden Organics have an impressive repertoire of oils and capsules, but it’s their ginger snaps that have caught our eye. Each pack contains six ginger snaps with 10mg of CBD. They’re great for munchies and levelling out your high if it ever gets a little intense.

7) 4.20 Bar CBD Dark Chocolate by VCC Brands (CBD: 120mg, THC: 60mg)

A 2:1 CBD to THC ratio is just right for a chilled out time with more muted euphoric sensations, and that’s just what you get with this chocolate edible from VCC Brands. It’s a potent bar so if you’re low dosing, one segment will most likely be enough.

8) Marinara Pizza Sauce by Clean Healing (CBD: 20mg)

Not all CBD edibles are sweet, there are some divine savory products on the market too, like this rich Marinara Pizza Sauce. Every ounce of this Clean Healing sauce contains 20mg of CBD, allowing you to be liberal with the amounts you use. Spread it on your pizza, pasta, breadsticks or anything you think may go well with it.